Current Research Projects

Comparing a new whole‑body imaging technique with standard scans for detecting primary bone cancer spread

Comparison of the effectiveness of a new whole body imaging technique versus standard…

Engineering a laboratory tool to identify safer and more effective immunotherapies against Ewing sarcoma

Preclinical selection of STEAP1-targeting bispecific antibodies for Ewing Sarcoma using…

Crossing the line: transfer of the fusion protein from cancer to healthy cells

Crossing the Line: Horizontal Fusion Oncoprotein Transfer as a Mechanism of Immunosuppression…

New ways to help the immune system fight osteosarcoma:

Novel strategies to overcome immunosuppression in the tumour microenvironment

Novel Combination of Chemotherapy to fight Ewing sarcoma

Novel Combination Chemotherapy to Deplete Ewing Fusion Proteins

Developing TCR-T immunotherapy for the treatment of Ewing sarcoma

Developing TCR-T immunotherapy for the treatment of Ewing sarcoma

A data programme to transform patient care

ASPIRE: A Sarcoma data Partnership to Improve patient outcome and Reduce inEqualities

Exploring surrounding epigenetic influences in Ewing sarcoma

Exploring surrounding epigenetic influences in Ewing sarcoma

Brachyury targeting in chordoma

Evaluating the therapeutic potential of a new approach to targeting brachyury in human…

Exploring biomarkers in Ewing sarcoma: analysing blood samples from patients recruited to the rEECur clinical trial

The prognostic value of circulating tumour DNA and RNA and circulating IGF2BP3 protein…

Investigating the role of a PRMT5 in Ewing sarcoma and its potential as a target for treatment

Investigating the role of a PRMT5 in Ewing sarcoma and its potential as a target for treatment

Harnessing the immune system to treat Ewing sarcoma in the lungs

Harnessing the immune system to treat Ewing sarcoma in the lungs

A multi-faceted investigation of chondrosarcoma biology to inform targeted treatment

A multi-faceted investigation of chondrosarcoma biology to inform targeted treatment

Enabling early diagnosis of osteosarcoma – the SPEED study

DIAGNOSED: Data-driven Integrated Approach to Generate Novel Opportunities for Sarcoma…

Stopping the alpha - a potential new treatment approach for osteosarcoma

Mimicking the journey through the bloodstream: exploring how osteosarcoma cells spread and survive elsewhere in the body

Investigating individual cells to understand the key genetic changes leading to mesenchymal chondrosarcoma

Looking at the HEY1-NCOA2 fusion gene in mesenchymal chondrosarcoma as a potential target…

A novel therapeutic strategy for bone sarcoma treatment

Targeting the underlying biology of Ewing-like sarcomas to develop kinder treatment approaches

Does oestrogen have a protective effect in chondrosarcoma?

The Role of Oestrogen in Chondrosarcoma Using Patient-Derived Xenograft Models: A Pilot…

Novel immunotherapy approach against osteosarcoma

Overcoming osteosarcoma immunotherapy resistance through a novel, IL-12 driven approach

The impact of spine sarcoma on psychological wellbeing: an exploratory study

The impact of spine sarcoma on patient wellbeing

Towards better understanding adamantinoma to improve its diagnosis

Unravelling adamantinoma histogenesis

Identifying biomarkers for treatment response in Ewing sarcoma

Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma through an increased…

Advancing the ICONIC trial: Improving outcomes through Collaboration in Osteosarcoma

Advancing the ICONIC trial: Improving outcomes through Collaboration in Osteosarcoma

In-depth protein analysis to identify tailored treatments for chondrosarcoma patients

A deep dive into the proteomic landscape of chondrosarcoma: improving patient stratification…

Collecting patient samples for research

Supporting sample collection through Infrastructure Grants

Supporting rEECur – a clinical trial for recurrent and primary refractory Ewing sarcoma

Biological studies in rEECur, an international randomised controlled trial of chemotherapy…

Advancing technology for image guided surgery in bone sarcoma

Optimisation of fluorescence technology for bone sarcoma image guided surgery and photodynamic…

Towards precision medicine in Osteosarcoma

Developing genome-informed treatment to improve outcome in Osteosarcoma

Kinder drugs to treat osteosarcoma

Optimisation of tumour-targeted methotrexate prodrugs for osteosarcoma

Understanding osteosarcoma chemotherapy resistance

Cellular Dynamics of Chemotherapy Resistance in Osteosarcoma

Searching for new drugs to treat osteosarcoma

Preclinical validation of novel compounds to treat osteosarcoma

Developing an effective CAR T cell therapy for osteosarcoma

Towards Engineered T Cells for Osteosarcoma

Sensitising osteosarcoma to immunotherapy

Modulation of interferon gamma-mediated signalling and immune response by fibroblast growth…