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Making progress through collaboration

We believe that through collaboration we can make this biggest impact for patients.

  • PBCMetNet

    Primary Bone Cancer Metastasis Network (PBCMetNet) is a basic science and pre-clinical…

    More information

In this section Research

  • Research Strategy & Grant Programme
  • For Researchers
    • Grant success rates
  • Association of Medical Research Charities
  • Useful documents for researchers
  • The Independent Scientific Advisory Panel
  • Patient and Public Involvement Panel
  • 15 Years of Research — Working Towards a Cure
  • Research Impact Report 2023
  • Publications
  • Research Impact Report 2025
  • How we fund Research
  • Current Research Projects
    • A data programme to transform patient care
    • Novel Combination of Chemotherapy to fight Ewing sarcoma
    • Engineering a laboratory tool to identify safer and more effective immunotherapies against Ewing sarcoma
    • Crossing the line: transfer of the fusion protein from cancer to healthy cells
    • New ways to help the immune system fight osteosarcoma:
    • Identifying biomarkers for treatment response in Ewing sarcoma
    • Comparing a new whole‑body imaging technique with standard scans for detecting primary bone cancer spread
    • A novel therapeutic strategy for bone sarcoma treatment
    • DIAGNOSED: Data-driven Integrated Approach to Generate Novel Opportunities for Sarcoma Early Diagnosis in primary care
    • Investigating individual cells to understand the key genetic changes leading to mesenchymal chondrosarcoma
    • Developing TCR-T immunotherapy for the treatment of Ewing sarcoma
    • Exploring surrounding epigenetic influences in Ewing sarcoma
    • Supporting rEECur – a clinical trial for recurrent and primary refractory Ewing sarcoma
    • Exploring biomarkers in Ewing sarcoma: analysing blood samples from patients recruited to the rEECur clinical trial
    • Investigating the role of a PRMT5 in Ewing sarcoma and its potential as a target for treatment
    • Harnessing the immune system to treat Ewing sarcoma in the lungs
    • Brachyury targeting in chordoma
    • Towards precision medicine in Osteosarcoma
    • Novel immunotherapy approach against osteosarcoma
    • Enabling early diagnosis of osteosarcoma – the SPEED study
    • Stopping the alpha - a potential new treatment approach for osteosarcoma
    • Mimicking the journey through the bloodstream: exploring how osteosarcoma cells spread and survive elsewhere in the body
    • Sensitising osteosarcoma to immunotherapy
    • Developing an effective CAR T cell therapy for osteosarcoma
    • Advancing the ICONIC trial: Improving outcomes through Collaboration in Osteosarcoma
    • In-depth protein analysis to identify tailored treatments for chondrosarcoma patients
    • A multi-faceted investigation of chondrosarcoma biology to inform targeted treatment
    • Understanding osteosarcoma chemotherapy resistance
    • Searching for new drugs to treat osteosarcoma
    • Kinder drugs to treat osteosarcoma
    • Collecting patient samples for research
    • The impact of spine sarcoma on psychological wellbeing: an exploratory study
    • Advancing technology for image guided surgery in bone sarcoma
  • Completed Research Projects
    • A potential new non-invasive biomarker for chordoma
    • Exploring a new drug target to develop novel combination treatments for Chondrosarcoma
    • Unravelling the diversity of bone tumours: investigating the differences between single cancer cells.
    • Investigating the potential of signalling proteins to monitor and treat adamantinoma relapse and spread
    • Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma
    • Developing novel biomaterials for osteosarcoma and chordoma treatment
    • Haem oxygenase-1 (HO-1), a novel druggable target for prevention of osteosarcoma growth and metastasis
    • Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma
    • Novel tissue engineering technology to facilitate Osteosarcoma Research
    • International collaboration to optimise the management of patients with Ewing sarcoma
    • TP53 restoration using mRNA vaccine technology
    • ICONIC
  • Ewing Sarcoma Meetings 2026
    • The Euro Ewing Consortium Network Meeting 2026
    • Advances in Ewing Sarcoma Research 2026
  • Past research events
  • Making progress through collaboration
    • PBCMetNet
  • Pharmaceutical Policy
  • Animal Research Policy

Patient stories

To try and help, a number of families have kindly shared their personal experiences.

Read the stories
Bone Cancer Research Trust - Until There's a Cure

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